The Postoperative Analgesic Effect of Combination With Dexmedetomidine in Fentanyl-based Intravenous Patient Controlled Analgesia Compared With Conventional Thoracic Epidural and Intravenous Patient Controlled Analgesia After Radical Open Gastrectom

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study to test hypothesis that addition of dexmedetomidine to fentanyl based intravenous patient controlled analgesia (PCA) improves postoperative pain compared with conventional thoracic epidural and intravenous patient controlled analgesia after radical open gastrectomy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yonsei University
• Treatments: Dexmedetomidine; Fentanyl

Criteria

Inclusion Criteria:

1. ASA class I-II

2. obtaining written informed consent from the parents

3. aged 20-65 years who were undergoing radical open gastrectomy

Exclusion Criteria:

1. abdominal surgery previously

2. patient who refuse the patient controlled analgesia

3. unstable angina or congestive heart failure

4. uncontrolled hypertension (diastolic bp>110mmHg)

5. coagulopathy

6. hepatic failure

7. renal failure

8. bradycardia on EKG (under 50 bpm)

9. Ventricular conduction abnormality

10. drug hyperactivity

11. neurological or psychiatric illnesses

12. mental retardation

13. patients who can't read the consent form due to illiterate or foreigner 14.infection

15. pregnant 16. obesity (BMI > 30kg/m2)