Overview

The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: a Randomized Clinical Trial

Status:
NOT_YET_RECRUITING

Trial end date:
2026-08-31

Target enrollment:

Participant gender:

Summary

Brief Summary of the Study This study investigates the effects of locally administered vitamins C and E on orthodontic tooth movement during the initial stage of treatment. Orthodontic tooth movement relies on bone remodeling, which can be influenced by antioxidants like vitamins C and E. Vitamin C promotes collagen formation and osteoblast activity, while vitamin E has anti-inflammatory and antioxidant properties that may impact bone metabolism. The study is a randomized clinical trial conducted in multiple clinics, where patients will be divided into three groups: 1. Control group - receives a saline injection. 2. Vitamin C group - receives a local injection of vitamin C. 3. Vitamin E group - receives a local injection of vitamin E. Injections will be administered every two weeks for six months, while patients undergo orthodontic treatment with fixed appliances. Researchers will evaluate the rate of tooth movement, root resorption, pain perception, and patient experience. Additionally, biomarkers related to bone remodeling will be measured in gingival crevicular fluid at different time points. The study aims to determine whether local administration of vitamins C or E enhances orthodontic tooth movement and elevate their effects on the orthodontic potential side effects like root resorption and pain. The findings may provide valuable insights into optimizing orthodontic treatment with the help of antioxidants.

Phase:

PHASE1

Details

Lead Sponsor:

University of Baghdad

Treatments:

Saline Solution