The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids
Status:
Completed
Trial end date:
2006-08-01
Target enrollment:
Participant gender:
Summary
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic
activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free
fatty acids are responsible for this association. The investigators hypothesize that in
patients with obesity and the metabolic syndrome, an increased intracellular concentration of
long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces
an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and
sympathetic activation.
The investigators aimed to assess this effect of free fatty acids on the adenosine system in
healthy volunteers.
Phase:
N/A
Details
Lead Sponsor:
Radboud University
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development