The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Gastro-Esophageal Reflux Disease was defined as a condition that develops when the reflux of
stomach contents causes troublesome symptoms and/or complications. Many drugs used for the
treatment of GERD such as omeprazole (a proton pump inhibitor) which is widely used
anti-ulcer drug and has been demonstrated to protect against esophageal mucosal injury.
Melatonin has been found to protect the gastrointestinal mucosa from oxidative damage caused
by reactive oxygen species in different experimental ulcer models. The aim of this study is
to evaluate the role of exogenous melatonin in the treatment of reflux disease in human
either alone and in combination with omeprazole therapy.