The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning

• Status: Recruiting
• Trial end date: 2021-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Aluminum phosphide (ALP) is a widely used fumigant due to its efficiency as pesticides. It is available as tablets of Celphos, Alphos or Quickphos which are known as rice tablets. Each tablet weights 3 grams and contains 56% ALP and 44% of aluminum carbonate and paraffin. The incidence of ALP poisoning increased steadily specially in developing countries . ALP poisoning is considered to be one of the major causes of suicidal poisoning owing to its wide accessibility and low cost. However, accidental poisoning may occur during occupational exposure

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Hydrocortisone; Hydroxyethyl Starch Derivatives

Criteria

Inclusion Criteria:

• Patients with severe acute aluminum phosphide poisoning

• systolic blood pressure (SBP) ≤90 mmHg

• PH ≤ 7.2

• HCO3 ≤15 meq/L

• during the first six hours of admission

Exclusion Criteria:

• Pregnant and lactating women

• Asymptomatic patients with history of acute aluminum phosphide exposure.

• Patients with co-ingestion to other substances in addition to aluminum phosphide.

• Patients with other major medical conditions (e.g. cardiovascular disease, renal or hepatic failure).

• Patients with previous medical intervention (fluid therapy and vasopressors).