The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) Program

• Status: Recruiting
• Trial end date: 2023-09-30
• Target enrollment: 0
• Participant gender: All

Summary

The Pre-DICTED (Pre-Diabetes Intervention and Continued Tracking to Ease-out Diabetes) program is a community-based diabetes prevention program. This study aims to test the effectiveness of structured, group-based lifestyle interventions with stepwise addition of metformin, if required, among subjects with pre-diabetes in multi-ethnic Singapore.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Singapore General Hospital
• Collaborators: Duke-NUS Graduate Medical School; Health Promotion Board, Singapore; Ministry of Health, Singapore; Singapore Clinical Research Institute
• Treatments: Metformin

Criteria

Inclusion Criteria:

1. Singapore citizens or permanent residents

2. Age between 18 and 64

3. Body mass index (BMI) ≥ 23.0 kg/m2

4. Pre-diabetes diagnosed based on:

1. fasting plasma glucose 6.1 - 6.9 mmol/L (Impaired fasting glucose; IFG) and/or

2. 2-hr plasma glucose in 75g oral glucose tolerance test (OGTT) 7.8 - 11.0 mmol/L (Impaired glucose tolerance; IGT) (Laboratory tests to be done within 6 months of enrolment)

Exclusion Criteria:

1. Individuals with diabetes mellitus

2. Health conditions impeding participation in lifestyle change programme (e.g. active cancer, recent myocardial event within 6 months, heart failure, chronic kidney disease)

3. Current pregnancy or breast feeding

4. Treatment with medications known to alter glucose tolerance

5. Known allergic reaction to metformin