The Pre-Emptive Administration Of Ketamine for Controlling Post-thoracotomy Pain

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this paper is to evaluate whether the pre-emptive administration of Ketamine would potentiate the effect of intravenous morphine analgesia in management of post thoracotomy pain. This was a single center, double-blind, placebo controlled, parallel-group, prospective study. Patients were randomly assigned to receive 1 mg/kg ketamine (Ketamine Group) or an equivalent dose of normal saline (Placebo Group) before thoracotomy in 1:1 ratio. All patients received postoperatively intravenous morphine administration as additional analgesic regimen Primary end-point was pain relief measured with Visual Analogue Scale at rest. The secondary end-points were the reduction of inflammatory response expressed by plasma c-reactive protein levels, the morphine consumption, and the rate of side effects. The measurements were carried out 6; 12; 24; 36; and 48 post operative hours.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Campania "Luigi Vanvitelli"
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• aged more than 18 years old,

• planned for an elective partial pneumonectomy (partial or total lobectomy involving one or more lobes, except total pneumonectomy)

• standard lateral thoracotomy for management of non small cell lung cancer (NSCLC)

Exclusion Criteria:

• allergy to Ketamine

• ASA score more than 3

• previous thoracic surgical procedures or lung resection

• mental disease

• participation to other studies

• lack of written informed consent.