The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to evaluate the predictors of success of oral dissolution therapy in radiolucent renal stones in a large series of patients from a tertiary referral center in order to define the optimum case scenarios where oral dissolution therapy could be implemented.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Allopurinol; Citric Acid; Potassium Citrate; Uric Acid

Criteria

Inclusion Criteria:

• Patients' criteria:

1. Ability to give informed consent.

2. Age more than 18 years.

3. Absence of significant hydronephrosis, serious urinary tract infection, congenital anomalies or distal ureteric obstruction in the affected renal unit.

4. Normal cardiac, hematological, and renal functions.

• Stone criteria:

1. Primary or recurrent renal stone.

2. Patients with residual renal stones after primary intervention whether open surgery, endoscopic or ESWL.

3. Peripheral calyceal stones or stone in the renal pelvis with no significant hydronephrosis.

4. Stone size less than 3 cm in maximum diameter

5. Stones with radiodensity less than 600 Hounsefield units attenuation in Non Contrast Computed Tomography (NCCT).

Exclusion Criteria:

• Patients' criteria:

1. Inability to give informed consent.

2. Age less than 18 years

3. Patients with unremitting pain or serious urinary tract infection.

4. Presence of significant hydronephrosis, congenital anomalies or distal ureteric obstruction in the affected renal unit.

5. Abnormal cardiac, hematological or renal functions.

• Stone criteria:

1. Obstructing stone in the renal pelvis with significant hydronephrosis.

2. Assumption of presence of calcium stones by presence of calcification in the stone in plain X-rays.

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