The Prehospital Administration of Normobaric Oxygen in Suspected Stroke

• Status: Recruiting
• Trial end date: 2022-10-20
• Target enrollment: 0
• Participant gender: All

Summary

The primary purpose of this study is to explore the feasibility and safety of normobaric oxygen therapy (NBO) under pre-hospital condition in patients with suspected stroke.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Capital Medical University

Criteria

Inclusion Criteria:

1. Age 18 years or more.

2. Suspected stroke screened by the "Gaze- Face Arm Speech Time" scale (G-FAST score ≥ 1).

3. Within 24 hours of symptom onset

4. SpO2 > 94%.

Exclusion Criteria:

1. Coma: Glasgow coma score (GCS) < 8.

2. Hypoglycemia: Blood glucose < 2.8mmol /L.

3. Known history of seizure.

4. Recent stroke or brain trauma within past 30 days.

5. Previous Modified Rankin Scale (mRS) ≥2.

6. Rapid improvement of neurological dysfunction (deficit present less than 15 min).

7. Unstable vital signs.

8. Known respiratory distress, respiratory dysfunction, or any contraindications to high-flow oxygen inhalation therapy.

9. Patient unable to cooperate with the trial procedure.

10. Any condition which might increase the risk to the patient in the judgment of the investigator.

11. Patient or available legally authorized representative unable to provide written or witnessed oral consent.