The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population

• Status: Recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study to determine the therapeutic response of non-allergic rhinitis patients that have been subtyped as non-allergic rhinitis with local IgE elevation or non-allergic rhinopathy to intranasal capsaicin based on visual analog scale and optical rhinometry, to determine the prevalence of non-allergic rhinitis with local IgE elevation in this study's cohort of patients with non-allergic rhinitis identified by rhinitis history and negative skin testing for allergic rhinitis, and to determine the change, if any, in intranasal IgE levels after capsaicin treatment.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Collaborator: American Academy of Otolaryngic Allergy & Foundation
• Treatments: Capsaicin; Lidocaine

Criteria

Inclusion Criteria:

• Chronic rhinitis

Exclusion Criteria:

• Active smoker

• Anatomic source of nasal symptoms

• Chronic rhinosinusitis or other nasal infection

• History of sinonasal malignancy

• Pregnancy or lactation

• Use of medication affecting nasal function (topical steroids, topical anticholinergics, oral antihistamines) in the previous 4 weeks

• Use or abuse of nasal decongestants.

• Positive skin prick test for allergic rhinitis