The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Department
Status:
Completed
Trial end date:
2019-01-01
Target enrollment:
Participant gender:
Summary
Consecutive patients aged 18-65 years who go to the gastroenterology clinic presented with
upper gastrointestinal discomfort would be included. All patients underwent upper endoscopy
or an ambulatory 24-h pH(Potential Of Hydrogen) monitoring.Pathologic esophageal acid reflux
was defined as the percentage total time for which a pH value < 4 was >4.2 % in the distal
esophagus. Then, patients were treated with esomeprazole 20 mg twice daily for 28 days. The
symptom scores were measured by the frequency score multiplied by the severity scores of the
predominant symptom before and at the end of the treatment, and the " PPI test " was defined
as positive if the overall scores of the predominant dyspeptic symptom in the fourth week
decreased by >50 % compared with those of the baseline.
GERD is defined by either 24-hour impedance-pH monitoring or positive PPI(proton pump
inhibitor) test or positive result from endoscopy. The percentage of each symptom of GERD in
the symptom questionnaire in Chinese outpatients in Gastroenterology department will be
calculated. The symptom of the highest percentage will be the primary symptom.