The Relationship Between Intraocular Pressure and Macular Edema in Patients With Diabetic Macular Edema

• Status: Unknown status
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The Investigators propose to examine the effect of lowering the intraocular pressure on macular edema in Participants diagnosed with diabetic macular edema. Our theory is based on the assumption that lower intraocular pressure means higher Ocular Perfusion pressure, which may cause an improvement in retinal perfusion and thus an improvement in retinal oxygenation and reduced edema

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Meir Medical Center
• Collaborator: Meir Hospital, Kfar Saba, Israel
• Treatments: Brimonidine Tartrate; Brimonidine Tartrate, Timolol Maleate Drug Combination; Ophthalmic Solutions; Timolol

Criteria

Inclusion Criteria:

• Participants with a diagnosis of diabetic macular edema over the age of 18 which are eligible to sign an agreement to participate in the study

• Presence of DME (based on clinical examination of retinal specialist + OCT) in both eyes with an edema thickness ranged from 350 to 800 microns

• Media lucid enough to allow sufficient quality photographs by OCT

Exclusion Criteria:

• Patients which do not have a valid diagnosis of DME (Diabetic Macular Edema)

• Patients with problems that can cause macular edema in any other:

• Age-Related Macular Degeneration

• Central retinal vein occlusion (CRVO)/Branch retinal vein occlusion (BRVO) /central retinal artery occlusion (CRAO) / branch retinal artery occlusion (BRAO)

• Epiretinal membrane (ERM) or Vitreo-macular traction (VMT)

• Patients who are Pseudophakic in one eye or pseudophakic in both eyes for less than a year

• Patients treated in order to reduce the DME by intra-vitreal injection or by laser in the past six months

• Patients which are currently treat with Intra ocular Pressure lowering drops in at least one eye, or have been treated in the past with laser of any kind or with surgery

• Patients who underwent Pars plana vitrectomy one or both eyes

• Patients who cannot undergo an OCT examination

• Patients who want prefer to be treated by the current practices based on clinical judgment

• Patients with a condition that requires an intervention or laser surgery during the 3 months of study, such as active Proliferative diabetic retinopathy, vitreous hemorrhage or other similar conditions