The Renin-Aldosterone Axis in Postural Tachycardia Syndrome

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Vanderbilt University Medical Center
• Treatments: Angiotensin II; Angiotensinogen; Giapreza

Criteria

Inclusion Criteria:

• Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria

• Age between 18-64 years

• Male or females are eligible

• Able and willing to provide informed consent

• Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study

Exclusion Criteria:

• Overt cause of postural tachycardia e.g., dehydration

• Inability to give or withdraw informed consent

• Pregnancy

• Hypertension (BP > 140/90)

• Significant co-morbid condition

• Other factors which in the investigator's opinion would prevent the subject from completing the protocol