The Rilpivirine Cerebrospinal-fluid (CSF) Study

• Status: Completed
• Trial end date: 2013-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

This is a phase I pharmacokinetic study of HIV positive patients stable on antiretroviral therapy who will switch treatment when enrolled from nevirapine to rilpivirine. On day 60 of the study the participants will attend clinic where they will have blood collected followed by a lumbar puncture where cerebrospinal fluid will be collected to measure drug concentration. The participants will then restart their original regime with nevirapine.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Imperial College London
• Collaborator: Janssen-Cilag Ltd.
• Treatments: Rilpivirine

Criteria

Inclusion Criteria:

• HIV-1 infected males subjects

• signed informed consent

• willing to switch therapy as per study protocol

• no previous exposure to rilpivirine

• plasma HIV RNA < 50 copies/mL at screening and on at least one other occasion over the last 3 months

• currently receiving a stable antiretroviral regimen comprising of TDF/FTC with nevirapine with nevirapine dosed either 200 mg twice daily or 400 mg once daily with no antiretroviral drug switches for at least 3 months

• no clinically-significant resistance documented on any prior HIV-1 genotypic resistance testing

• subjects in good health upon medical history, physical exam, and laboratory testing

• BMI above or equal to 18 and below 32

• Male subjects who are heterosexually active must use two forms of barrier contraception (e.g., condom and diaphragm) during heterosexual intercourse, from screening through completion of the study.

• Have local screening laboratory results (haematology and chemistry that fall within the normal range of the central laboratory's reference ranges unless the results have been determined by the Investigator to have no clinical significance

• No contraindications to having a lumbar puncture examination found on MRI of the brain

Exclusion Criteria:

• current alcohol abuse or drug dependence

• positive urine drug of abuse screening

• active opportunistic infection or significant co-morbidities

• current disallowed concomitant medication (as listed in section 4.1.3)

• contraindication to MR examination or lumbar puncture examination

• recent head injury (in last 30 days) or chronic ongoing neurological diseases