The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex. An increasing body of evidence suggests a role for aldosterone in augmenting the exercise pressor reflex in hypertensive humans. We hypothesize that this effect of aldosterone is mediated by its direct action on the central nervous system and that administration of mineralocorticoid receptor antagonists constitute an effective treatment for EPR overactivity in hypertension, independent of reductions in resting BP.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Amlodipine; Eplerenone; Polystyrene sulfonic acid; Spironolactone; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• Experiments will be performed on 3 groups of nondiabetic human subjects:

• 1) stage I (140-159/90-99 mmHg) subjects with essential hypertension.

• 2) stage I hypertensive subjects with primary aldosteronism

• 3) normotensive controls.

Exclusion Criteria:

• 1) Any evidence of cardiopulmonary disease, left ventricular hypertrophy or systolic dysfunction by echocardiography.

• 2) Blood pressure averaging ≥160/100 mmHg

• 3) Estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m2

• 4) Diabetes mellitus or other systemic illness

• 5) Pregnancy

• 6) Hypersensitivity to nitroprusside, phenylephrine, amlodipine or eplerenone

• 7) Any history of substance abuse or current cigarette use

• 8) Any history of psychiatric illness

• 9) History of malignancy