The Role of Bexarotene in Inducing Susceptibility to Chemotherapy in Metastatic TNBC
Status:
Recruiting
Trial end date:
2023-06-30
Target enrollment:
Participant gender:
Summary
Triple-negative breast cancer (TNBC) is biologically aggressive and has limited systemic
treatment options, often compounded by treatment resistance.
Cell state transitions, e.g. epithelial-to-mesenchymal transition (EMT) govern cancer cell
behaviour.
The investigators hypothesize that by inducing change in cell state change, TNBC cells that
have manifested taxane-resistance will be more sensitized to subsequent chemotherapy.
Phase:
Phase 1
Details
Lead Sponsor:
National Cancer Centre, Singapore
Collaborator:
National Medical Research Council (NMRC), Singapore