Overview

The Role of Cathepsin X in Infection With the Helicobacter Pylori

Status:
Unknown status

Trial end date:
2010-07-01

Target enrollment:
0

Participant gender:
All

Summary

The immune response to Helicobacter pylori (Hp) importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria. The investigators want to demonstrate the importance of cathepsin X (CTSX), a cysteine protease, for the Hp eradication success. The diversity of the innate immune response to H. pylori antigens leading to either successful eradication of the infection or maintenance of chronic inflammation is connected to CTSX. The aim of this study is to determine whether H. pylori suppresses the CTSX expression and cytokine secretion in macrophage cell line THP-1 in the individuals that are not capable of eradicating the infection, opposite to H pylori in patients with successful H pylori eradication . The investigators also investigate the possibility whether strain-dependent differences in H. pylori lipopolysaccharide (LPS) influence the CTSX expression and cytokine secretion.

Accepts Healthy Volunteers?

Details

Lead Sponsor:

University Medical Centre Ljubljana

Treatments:

Clarithromycin
Metronidazole
Proton Pump Inhibitors

Criteria

Inclusion Criteria:People with helicobacter gastritis and Helicobacter sensitive to
antibiotic therapy but failure of therapy -

Exclusion Criteria:People with helicobacter gastritis who did not eradicate Helicobacter
pylori because of primary resistance to antibiotics.

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