The Role of Dysbiosis of Gut Microbiota in the Pathogenesis of PCOS.
Status:
Unknown status
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome (PCOS) has a significant impact on women's health, but its
pathogenesis is not yet clear. Dysbiosis of gut microbiota may play a role in the
pathological change of PCOS. Most of the current researches are still limited to the use of
amplicon sequencing to compare the basic taxonomic differences of gut microbiota between PCOS
patients and normal controls. Overall analysis of microbiome species, genes, function,
metabolism, and immunity in PCOS is still lacked. In this research, we would perform
metagenomic sequencing to find the characteristics of gut microbiota of PCOS and to explore
their correlations with metabolic, immune, and clinical symptoms. Finally, different
interventions (lifestyle interventions, lifestyle interventions + oral probiotic, lifestyle
interventions+ compound oral contraceptives) would be used to explore the change of gut
microbiome in PCOS patients. This research will not only help the understanding of the
pathophysiology of PCOS, but also provide a reference for the selection of clinical treatment
options.