The primary goal of the study is to determine the safety and tolerability of ambrisentan. It
is also expected that ambrisentan will improve blood flow in the lungs, decrease
inflammation, and reduce pain in sickle cell patients. An additional goal is to evaluate the
use of select biomarkers in evaluating sickle nephropathy.
Phase:
Phase 1
Details
Lead Sponsor:
Augusta University
Collaborators:
Gilead Sciences National Heart, Lung, and Blood Institute (NHLBI)