The Role of Igf-1 Generation Test in Diagnosis and Treatment of Short Stature

• Status: Withdrawn
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate the predictive value of IGF-1 generation test for growth velocity during GH treatment for 12 months.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Maimonides Medical Center
• Treatments: Hormones

Criteria

Inclusion Criteria:

• ability to provide written informed consent

• Prepubertal males and females form 5- 11years old

• Bone age <11 years in males and <9 years in females

• Height SD score<-2.25SD in males and females

• IGF-1SD score <-1SD in both males and females

• Peak GH level after stimulation >10ng/ml

Exclusion Criteria:

• History of prior chemotherapy and or radiation

• Active neoplasm

• Pediatric patients with closed epiphyses

• Prader-Willi syndrome, Turner syndrome or any other genetic or chromosomal anomaly

• Treatment with inhaled or systemic steroids

• BMI <5th percentile or >95th percentile

• Tanner 2 at clinical or biochemical examination by ultrasensitive LH and FSH