The Role of Intra-articular Injection of PRP Versus Corticosteriods in Treatment of Lumbar Facet Disease

• Status: Completed
• Trial end date: 2021-01-22
• Target enrollment: 0
• Participant gender: All

Summary

Low back pain is an extremely common health problem and recent studies have shown that nearly up to 52% of patients have low back pain caused by lumbar facet joint syndrome. Intra-articular injection of facet joints has gradually become one of the vital therapeutic methods for lumbar facet joint syndrome, Steroid is one of the most commonly used injected drugs; however, previous studies have indicated that it has limited ability in long-term relief of low back pain. Therefore, it seems meaningful to apply a new injectable drug and to prove its effectiveness and safety for the treatment of lumbar facet joint syndrome. Recent studies indicate that autologous platelet rich plasma(PRP) is an appropriate injectable material with great potential in treating many different musculoskeletal disorders and currently it is not yet used on a wide scale as a treatment for lumbar facet joint synovitis. In this study the investigators compare the efficacy and safety of Intra-articular injection of PRP versus conventional steriods in patients with lumbar facet joint synovitis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Betamethasone; Lidocaine

Criteria

Inclusion Criteria:

• • Continuous or intermittent gradually progressive back pain for more than 3 months not significantly improving on medical treatment and/or physical modalities.

• Patients age between 20 and 40 years.

• Local / paraspinal pain or tenderness with or without radiation to buttock , groin or thigh.

• Increase of pain on extension , rotation or lateral bending .

• MRI detected synovitis of the facet joint as defined and graded by Czervionke and Fenton, 2008.

Exclusion Criteria:

• • Acute low back trauma, fractures, malignancies and inflammatory diseases.

• Pain score of < 4 at rest on visual analog scale.

• Radicular neurologic complaints.

• X-ray findings of long standing facet joint disease as; marked joint space narrowing, subchondral sclerosis or bone deformity/ sponylolithesis.

• Evident disc herniation by MRI.

• Prior surgery on the spine.

• Prior interventional treatment on lumbar facet joints

• Known hypersenstivity to local anesthesia, corticosteroid, contrast medium or blood derivatives.

• Local or systemic infection or spinal infection.

• Uncorrectable coagulopathy

• Diabetes Mellitus

• Pregnancy