The Role of Isolated Nocturnal Hypertension Pattern in Nondialysis CKD

• Status: Not yet recruiting
• Trial end date: 2023-12-30
• Target enrollment: 0
• Participant gender: All

Summary

Isolated nocturnal hypertension (INH) has been studied among the general population and hypertensive patients. However, little insight is available on the prognostic effect of INH in patients with chronic kidney disease (CKD). This study investigated the prognostic effect of INH in a cohort of Chinese patients with nondialysis CKD.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University
• Treatments: Losartan

Criteria

Inclusion Criteria:

• daytime BP <135/85mmHg，nighttime BP≥120/70mmHg；；

• presence of CKD;

• estimated GFR (eGFR)<90 mL⁄ min ⁄ 1.73 m2 (using the Modification of Diet in Renal Disease Study equation) but >30 mL⁄ min ⁄1.73 m2;

• signed informed consent from participating patients.

Exclusion Criteria:

• pregnancy;

• tumor;

• infection;

• renal replacement;

• history of drug or alcohol abuse;

• night- or shift-work employment;

• treatment with steroids or hormonal therapy;

• acute changes in eGFR >30% in the past 3 months;

• presence of acquired immunodeficiency syndrome;

• CV disorders (unstable angina pectoris, heart failure, life-threatening arrhythmia, atrial fibrillation, kidney failure,and grade III or IV retinopathy);

• intolerance to ambulatory BP monitoring (ABPM);

• inability to communicate and comply with all of the study requirements.