The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia

• Status: Recruiting
• Trial end date: 2023-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Optimal multimodal opioid-sparing analgesic technique is considered as one of the most important Enhanced recovery pathways (ERPs) or enhanced recovery after surgery (ERAS) interventions that mitigate the undesirable effects of surgical stress response. Implementation of ERP has been shown to reduce postoperative complications and shorten the hospital LOS.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Fayoum University Hospital
• Treatments: Dexmedetomidine; Ketamine

Criteria

Inclusion Criteria:

• Age 18 - 65 years

• Ejection fraction (EF) > 35%

• Elective isolated CABG

• Valve surgery, Atrial septal defect (ASD) closure

• Cross clamp time ≤ 90 min

• Cardiopulmonary bypass time ≤ 120 min.

Exclusion Criteria:

• Poor left ventricular function with intra-aortic balloon pump support

• Recent myocardial infarction (last seven days)

• Combined procedure (i.e., CABG + other heart/vascular procedure)

• Emergency surgery, and Redo surgery,Hepatic or renal failure, creatinine >1.5 -History of neurological disorders or convulsions