The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition

• Status: Recruiting
• Trial end date: 2021-09-10
• Target enrollment: 0
• Participant gender: All

Summary

The invesigators propose a clinical study on patients undergoing carotid surgery (endarterectomy). The invesigators will determine carotid artery imaging features associated with (1) vessel wall inflammation, (2) downstream brain inflammation, and (3) cognitive benefit from surgery. This project will uncover links between inflamed carotid plaque and downstream brain inflammation. The invesigators will also determine carotid plaque imaging features predicting cognitive benefit from carotid surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Scott Mcnally
• Collaborator: American Heart Association
• Treatments: Flutemetamol

Criteria

Inclusion Criteria:

• Patients ≥18 years old and plans for carotid endarterectomy.

Exclusion Criteria:

• Patients with carotid occlusion will be excluded, due to one carotid contributing to both right and left brain blood supply.

• Other known sources of cardioembolism, including atrial fibrillation, mechanical heart valve, left atrial or ventricular thrombus or intracardiac mass, endocarditis, EF <30%

• Known stroke mimics including multiple sclerosis or brain tumor

• MRI contraindications per ACR guidelines, including patients with pacemakers, renal failure with eGFR<30 ml/min/1.73m2, and contrast allergy

• [18F]Flutemetamol contraindications per manufacturer guidelines, including patients with prior reactions

• Known stage IV malignancy

• Pregnancy