Overview

The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain

Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
All
Summary
Patients are already receiving an intravitreal injection as a standard of care, but they are consenting to receiving a loteprednol drop following the intravitreal injection. This clinical trial is studying the role of loteprednol (corticosteroid) in reducing pain following intravitreal injections for patients with age-related macular degeneration. As of now, there is no definitive pain management technique following intravitreal injections. Loteprednol is a corticosteroid widely used in ophthalmology to treat pain and inflammation, however, it has not been studied as a treatment for pain following intravitreal injections. Our overall goal is to manage pain to improve quality of care after intravitreal injections. Participants will be given either loteprednol, nepafenac (NSAID comparison), or artificial tears following one visit for an intravitreal injection to test how effective loteprednol is in pain reduction. Pain levels will be assessed by asking participants over the phone about their pain from a scale of 0 to 10 at three different times over a 1-week period. Artificial tear and medication usage will also be tracked over a 1-week period.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Virginia Polytechnic Institute and State University
Collaborator:
Vistar Eye Center
Treatments:
Loteprednol Etabonate
Lubricant Eye Drops
Nepafenac
Ophthalmic Solutions
Criteria
Inclusion Criteria:

- All patients must have age-related macular degeneration and be undergoing intravitreal
injections for treatment as defined by a retina specialist.

Exclusion Criteria:

- Dementia

- Report baseline eye pain

- Use topical NSAIDs or steroids

- Patient under 18 years old

- History of corticosteroid responsive elevation in intraocular pressure

- Allergy to Loteprednol or Nepafenac

- Pre-existing chronic pain disorders

- Advanced Glaucoma

- Herpes zoster

- Allergy to local anesthetic or penicillin

- Patients unable to consent on own behalf

- Patients unable to communicate pain

- Pregnancy

- Incarceration