The Role of Mitochondrial Respiration in the Cardioprotective Capacity of IPC in Diabetic and Non-diabetic Patients
Status:
Completed
Trial end date:
2019-02-01
Target enrollment:
Participant gender:
Summary
The overall aim of this study is to examine the role of mitochondrial respiration in human
diabetic tissue before and after ischemia. Furthermore we will examine the ability of
ischemic preconditioning (IPC) to preserve the mitochondrial function and hemodynamic
performance of both non-diabetic and diabetic fibers after ischemia. To increase our
understanding on the metabolic changes during ischemia in both non-diabetic and diabetic
tissue we will use Dimethyl Malonate and examine the impact of this blockade on post-ischemic
mitochondrial respiration.