The Role of Opioidergic Systems in Breathing Based Analgesia

• Status: Completed
• Trial end date: 2017-06-27
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this psychophysical and pharmacologic study is to determine if slow-breathing induced pain relief is mediated by endogenous opioids in response to intravenous (IV) administration of the opioid antagonist naloxone during noxious heat stimulation. We were also interested in disentangling the endogenous analgesic mechanisms supporting mindfulness-based analgesia.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Diego; Wake Forest University Health Sciences
• Treatments: Naloxone

Criteria

Inclusion Criteria:

• Normal volunteers with no history of chronic pain problems

• Volunteers had no prior meditation experience

• Volunteers could be male and non-pregnant females.

• Volunteers of all ethnic backgrounds were included.

Exclusion Criteria:

• Female volunteers could not be pregnant.

• They could not be taking opioids or antidepressants.

• Subjects with a repeated history of syncope, loss of consciousness, light headedness, nausea, dizziness, or vomiting in response to needles or blood could not participate in the study.

• Subject could not be using exogenous opiates for the complete duration of the study.