The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa

• Status: Completed
• Trial end date: 2016-02-22
• Target enrollment: 0
• Participant gender: Female

Summary

Decreased bone strength is a common and serious medical problem present in many women with anorexia nervosa, or disordered eating. Women with decreased bone strength are more likely to suffer broken bones than women with normal bone strength.

We are investigating whether a hormone that is naturally produced by the human body -- parathyroid hormone (PTH) -- can help strengthen the bones of women with anorexia nervosa.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: Eli Lilly and Company
• Treatments: Teriparatide

Criteria

Inclusion Criteria:

• Anorexia Nervosa

• Women, age 30-70 years

• Osteoporosis or history of clinical fractures (spine, wrist, hip or ribs)

Exclusion Criteria:

• Diseases known to affect bone metabolism

• Hyperparathyroidism

• Medications known to affect bone metabolism in last 12 weeks (or bisphosphonate use in last 1 year)

• Pregnant and/or breastfeeding

• Diabetes mellitus

• History of malignancy involving or affecting the bone, any active malignancy, and/or radiation therapy to the bone

• Fractures of a bone other than a finger or toe in last 1 year