The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients
Status:
Recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
This study is a prospective, randomized, controlled trial.The selected patients were randomly
divided into remazolam general anesthesia group and propofol + midazolam general anesthesia
control group according to computer randomization method. There were 65 patients in each
group. Remazolam general anesthesia group (R group): Remazolam 0.4 mg/kg for rapid induction
of loss of consciousness for anesthesia induction and 1 mg/kg/h for maintenance. Propofol +
midazolam general anesthesia control group (group P): propofol 1.5 mg/kg + midazolam 0.05
mg/kg slow intravenous push until the patient's consciousness disappeared, then propofol 4-8
mg/kg/h Anesthesia was maintained. Except for different sedative drugs, the analgesic and
muscle relaxant medication regimens were the same between the two groups. In the study, the
application of inhaled anesthetics, other benzodiazepines and anticholinergic drugs was
restricted, and the mean arterial pressure during the operation was kept above 60 mmHg to
avoid perioperative hypotension, hypoxemia, and hypercapnia. Warm measures were used to
maintain the patient's intraoperative body temperature above 36.0 °C. POD assessment was
performed on the day before surgery and on days 1-7 after surgery.