The Role of Vasopressin Antagonism on Renal Sodium Handling
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Vasopressin has primarily been considered to be a water and osmosis regulating hormone that
mediates its effects on renal aquaporin channels. Recent data suggest that vasopressin,
through its V2 receptor, may also modulate sodium homeostasis. The purpose of this human
physiology study was to test whether antagonism of the V2R alters urine sodium excretion in
normal healthy volunteers.