The Role of Vitamin D in Chronic Urticaria and Angioedema Treatment
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
This clinical study was designed based on our hypothesis that vitamin D plays an important
role in chronic urticaria and that high dose supplementation with vitamin D in subjects with
chronic urticaria will improve clinical response.
This clinical study will investigate our hypothesis in three Specific Aims:
1. Determine whether high dosing vitamin D supplementation (4000 IU/day) reduces medication
usage (primary outcome) and urticaria severity score (secondary outcome) in subjects
with chronic urticaria as compared to low dosing (600 IU/day).
2. Determine if high dosing of vitamin D (4000 IU/day) is safe and well-tolerated in
subjects with chronic urticaria with or without baseline vitamin D deficiency.
3. Investigate whether there is an association with serum 25-hydroxyvitamin D levels,
vitamin D receptor mRNA expression, and chronic urticaria severity.
Phase:
N/A
Details
Lead Sponsor:
University of Nebraska
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins