The Role of Vitamin D in Neuroinflammatory on Drug Resistant Epilepsy

• Status: Recruiting
• Trial end date: 2025-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The incident of epilepsy still very high in Indonesia, thus many patients become drug resistant epilepsy. As vitamin D has some anticonvulsant effect, the investigators want to study if an additional dose of vitamin D can help with the therapy responses.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: DINA KEUMALA SARI
• Treatments: Cholecalciferol; Vitamin D

Criteria

Inclusion Criteria:

1. Age 1 - 18 years

2. Drug-resistant epilepsy

3. Having at least 6 unprovoked seizures in the previous 3 months

4. No vitamin D treatment in the previous 6 months

5. Medication compliance

6. Agreeing to participate in the study

7. Having a social insurance

8. Parental agreement

Exclusion Criteria:

1. Treatments influencing the metabolism of vitamin D other than anticoagulants (rifamycin, isoniazid, ketoconazole, 5-FU fluorouracil, leucovorin)

2. Known hypersensitivity to vitamin D

3. Lost to follow up