The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The aim of this project is to explore whether the extinction of cue-reactivity following a
cue-exposure based intervention in volunteers with an alcohol dependence is facilitated by
drugs that increase NMDA-receptor function.
It is hypothesised that targeted treatment with D-Cycloserine prior to each extinction
training session enhances the effects on cue-reactivity.
Further, a significant correlation between the reduction of cue-reactivity and both reduced
craving and relapse probability is expected.