The Role of the Gut Microbiome in Modulating Physical Abilities in Humans

• Status: Withdrawn
• Trial end date: 2024-09-01
• Target enrollment: 0
• Participant gender: All

Summary

There is a growing body of evidence indicating the significant contribution of the gut microbiome to host health and disease. Furthermore, it has been shown that exercise may modify the microbiome composition. The diversity of athletes' gut microbiome was found higher compared to gender and age-matched controls. However, important mechanistic questions related to the possible associations between exercise and the human gut microbiome remain unanswered.

In this study, we propose to investigate using advanced state-of-the-art measurements of physical activity level and related metabolic parameters whether there is a connection between the microbiome and physical abilities in healthy participants and whether antibiotics consumption can influence host physical abilities and glycemic responses through changes induced in microbiome composition and function.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Eran Elinav; Weizmann Institute of Science
• Collaborator: Assaf-Harofeh Medical Center
• Treatments: Anti-Bacterial Agents; Ciprofloxacin; Metronidazole

Criteria

Inclusion Criteria:

• BMI<28

• Age - 20-35

• Use to exercise in one or more of the following sports areas: running, swimming, Zumba, dance or Aerobe class, football, basketball, functional training, volleyball, surfing, tennis, wrestling athletics.

• Exercise at least twice a week, for a minimum duration of 6 months.

Exclusion Criteria:

• Consumption of antibiotics or probiotics 3 months prior to the first day of the experiment.

• Diagnosis of type 1 or type 2 diabetes.

• Pregnancy, fertility treatments

• Chronic disease (e.g. AIDS, Cushing syndrome, CKD, acromegaly, hyperthyroidism etc.)

• Cancer and recent anticancer treatment

• Psychiatric disorders

• Coagulation disorders

• IBD (inflammatory bowel diseases)

• Bariatric surgery

• Alcohol or substance abuse

• BMI>28

• Any physical condition precluding the completion of a routine effort test