The Role of the Microbiota in the Systemic Immune Response
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
The objective of this study is to investigate the role of the gut microbiota in the systemic
priming of immune effector cells. Twelve healthy male volunteers, 18-35 years of age, will be
treated with broad spectrum antibiotics (ciprofloxacin, vancomycin, metronidazole) for seven
days, in order to deplete the gut microbiota. Blood and faeces will be sampled before, 24
hours and 6 weeks after the 7-day period of antibiotics. Main study endpoints include
laboratory parameters for inflammatory responses, functional assays (ex vivo stimulation
assay) and gut microbiota composition.
Phase:
N/A
Details
Lead Sponsor:
W.J. Wiersinga, MD, PhD
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development