The Role of the Noradrenergic System in the Nonmotor Symptoms of Parkinson's Disease
Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to learn about the role of noradrenergic system in the non-motor
symptoms of Parkinson's disease. In particular, researchers hope to better understand what
role the noradrenergic system may play in the regulation of blood pressure, cognition and
mood symptoms in patients with Parkinson's disease. With this information, future research
may explore treatments that target the noradrenergic system in order to better treat the
non-motor symptoms of Parkinson's disease.
The experimental drug used in some of the study assessments, yohimbine hydrochloride, is not
being tested as a potential treatment for Parkinson's disease. Yohimbine hydrochloride will
be used to manipulate the noradrenergic system during some of the assessments. By measuring
the amounts of hormones and neurotransmitters the body produces before and after yohimbine
hydrochloride administration, researchers can assess how well the noradrenergic system is
functioning.