The Role of the Opioid System in Placebo Effects on Pain and Social Rejection
Status:
Not yet recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
The current study probes the involvement of the opioid system in placebo effects on social
pain, using the opioid antagonist naloxone. 60 participants who recently experienced an
unwanted breakup will experience rejection-related stimuli and receive painful heat and
pressure stimuli during fMRI scanning. Participants will be randomized to receive either a
naloxone or saline nasal spray, and be informed that the spray is either saline, or an
effective pain and negative emotion reducing agent.