The SITE Study - Dexamethasone Ophthalmic Insert In OR on Day of Surgery Versus In-office Post-Op Day 1

• Status: Not yet recruiting
• Trial end date: 2022-02-28
• Target enrollment: 0
• Participant gender: All

Summary

To assess the safety and effectiveness of treatment with an intracanalicular dexamethasone (0.4mg) insert in the operating room following cataract surgery/intraocular lens implant (IOL) compared to insertion 1-day post-op.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Joseph Kavanagh, MD
• Treatments: Dexamethasone

Criteria

Inclusion Criteria:

• Subjects will be eligible for study participation if they:

1. Are an adult subject aged 65 years or older

2. Are planning to undergo non-complicated CCI CE/PCIOL in one or both eyes

3. Are willing and able to comply with clinic visits and study related procedures

4. Are willing and able to sign the informed consent form

Exclusion Criteria:

• Subjects are not eligible for study participation if they:

1. Have active infectious systemic disease

2. Have active infectious ocular or extraocular disease

3. Have unobstructed nasolacrimal duct in the study eye(s)

4. Have known hypersensitivity to dexamethasone or are a known steroid responder

5. Have a history of ocular inflammation or macular edema

6. Are currently being treated with immunomodulating agents in the study eye(s)

7. Are currently being treated with immunosuppressants and/or oral steroids

8. Are currently being treated with corticosteroid implant (i.e. Ozurdex)

9. Have a history of herpes simplex virus keratitis or present active bacterial, viral, or fungal keratitis in either eye

10. Have a history of complete punctal occlusion in one or both punctum

11. Currently use topical ophthalmic steroid medications

12. Are unwilling or unable to comply with the study protocol

13. Are determined by the Investigator to not be included for reasons not already specified (e.g., systemic, behavioral, or other ocular disease/abnormality) or if the health of the subject or the validity of the study outcomes may be compromised by the subject's enrollment