The Safety, Tolerability, and Effectiveness of Quetiapine in Postpartum Depression
Status:
Not yet recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Postpartum depression is a serious disorder that affects approximately 14% of women who have
recently given birth. Postpartum depression is either an episode of major depressive disorder
(only low periods) or bipolar disorder (periods of lows and highs).
Untreated postpartum depression can negatively affect the mother, the infant and the family.
Antidepressants are the most used treatments; however, for many women these drugs are not
useful, resulting in a pressing need for effective treatments for postpartum depression. Lack
of sleep is common after delivery and can trigger depression in some women. Quetiapine, a
drug used for bipolar disorder, major depressive disorder and occasionally sleeplessness has
not been well studied in postpartum depression. This study aims to find out how mothers
tolerate the drug and whether it is effective for postpartum depression. Results of this
study may help investigators carry out a larger study comparing quetiapine and placebo (a
sugar pill) in postpartum depression.