The Safety, Tolerability, and Efficacy of KD01 in Cervical Malignancies
Status:
RECRUITING
Trial end date:
2028-04-01
Target enrollment:
Participant gender:
Summary
The recombinant oncolytic adenovirus injection (KD01) primarily consists of a recombinant human type 5 adenovirus with a deletion in the E3 region, where the ADP gene is replaced by the tBID apoptosis protein gene. This virus exhibits a conditional replication capability, with a 27 base pair deletion in the E1A region corresponding to nucleotides 920-946 of Ad5. This trial is a researcher-initiated clinical study aimed at concurrently evaluating the safety, tolerability, and preliminary efficacy of intratumoral administration of KD01 in patients with cervical malignancies.