The Safety and Effectiveness of Local Injection of Antihistamines in Treatment of Inflammatory Skin Diseases
Status:
Recruiting
Trial end date:
2021-12-30
Target enrollment:
Participant gender:
Summary
The treatment of chronic inflammatory skin diseases is a difficult point in clinical
diseases, which mainly include patients with pathological scars, sarcoidosis and chronic
eczema. Chronic nodular lesions and long-term itching symptoms bring great physical and
mental pain to patients.
Long-term repeated treatments are required. At present, the most commonly used treatment is
intralesional injection of glucocorticoids. Long-term glucocorticoid injections have some
side effects, including pain, hypopigmentation, skin atrophy, pigmentation, telangiectasia
and menstrual disorders in women. There are a large number of clinical patients who still
lack safe and effective drugs, including children, pregnant women, patients with weakened or
defective immunity, and even patients with mild inflammatory skin diseases with mainly
itching symptoms.
The systemic and topical application of antihistamine drugs provides new ideas for the
treatment of inflammatory skin. As the most commonly used clinical antihistamine,
chlorpheniramine has a long history in the treatment of allergic diseases and can improve the
body's inflammatory state. At the same time, the drug has high safety and is suitable for
children and pregnant women, or patients with underlying diseases such as hypertension,
diabetes, and immunodeficiency diseases.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University