The Safety and Effectiveness of Zidovudine Plus Acyclovir in Patients With Early HIV Infection
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This double-blind, placebo-controlled study is designed to determine the long-term safety and
efficacy of concurrent oral Retrovir / Zovirax (AZT and ACV) therapy and oral AZT therapy
alone, in the treatment of early symptomatic HIV infection. Efficacy will be evaluated by
monitoring the incidence, severity, and time of development of opportunistic infections and
other manifestations of advanced symptomatic HIV infection. The effects of the combination
and single AZT therapy on immune function and viral replication will also be evaluated. Study
participants will be monitored for evidence of toxicity or intolerance to concurrent AZT /
ACV administration and AZT therapy alone.