The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS

• Status: Completed
• Trial end date: 1991-11-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the safety and effectiveness of clindamycin and primaquine in the treatment of mild Pneumocystis carinii pneumonia (PCP) in AIDS patients.

As many as 80 percent of AIDS patients experience at least one episode of PCP and about one-third of these patients have a recurrence of the disease. Drugs currently used for treatment of acute PCP are toxic to the majority of AIDS patients. The combination of clindamycin and primaquine reduces the numbers of PCP organisms in laboratory tests and in animal studies. Both drugs can be given orally, concentrate in lung tissue, and have been used safely in humans for treatment of other diseases. It is possible that the combination may prove to be as good or better than standard therapy for PCP and side effects may be less.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Primaquine

Criteria

Inclusion Criteria

Concurrent Medication:

Allowed:

• Oral antiemetics.

Patients must have the following for inclusion:

• HIV positive by ELISA, p24 antigen or culture.

• Pneumocystis carinii pneumonia (PCP).

• Patients must have an (A-a) DO2 < 40 mmHg on room air.

• Willingness to sign an informed consent.

Prior Medication:

Allowed:

• Prophylaxis for Pneumocystis carinii pneumonia (PCP) with agents other than clindamycin and primaquine.

Exclusion Criteria

Concurrent Medication:

Excluded:

• Hematotoxic therapy, including zidovudine (AZT) or ganciclovir.

Patients with the following are excluded:

• History of allergy to clindamycin, lincomycin, or related drugs; or to primaquine or related drugs.

• Positive screen for G6PD deficiency, known NAD methemoglobin reductase deficiency, and/or known hemoglobin M abnormality.

• Concomitant conditions defined in Patient Exclusion Co-Existing Conditions.

• Any medical or social situation which, in the opinion of the investigator, would adversely affect participation in the study.

• Note:

Patients may be enrolled while G6PD screen is pending, but must be withdrawn if results are not known within 5 days after entry.

Prior Medication:

Excluded within 14 days of study entry:

• Systemic steroids at doses exceeding physiologic replacement or other investigational agents.

• Excluded within 6 weeks of study entry:

• Prior institution of any antiprotozoal therapy for the current episode of Pneumocystis carinii pneumonia or prophylaxis.

Patients must not have any of the following symptoms or diseases:

• History of allergy to clindamycin, lincomycin, or related drugs; or to primaquine or related drugs.

• Positive screen for G6PD deficiency, known NAD methemoglobin reductase deficiency, and/or known hemoglobin M abnormality.

• Diarrhea, defined as = or > 3 watery stools per day.

• Severe nausea and vomiting or other medical condition, such as ileus, that precludes oral therapy.

• Ventilator dependence or (A-a) DO2 = > 30 mm Hg.

• Any medical or social situation which, in the opinion of the investigator, would adversely affect participation in the study.

• Note:

Patients may be enrolled while G6PD screen is pending, but must be withdrawn if results are not known within 5 days after entry.