The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers

• Status: Unknown status
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this prospective study is to identify risk factors which could predict poor fading of SRH or early recurrent bleeding of peptic ulcer hemorrhage after successful endoscopic hemostasis and high-dose PPI infusion. These risk factors will be the selection criteria for patients who are indicated to receive second-look endoscopy.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cheng-Kung University Hospital
• Collaborator: National Science Council, Taiwan
• Treatments: Esomeprazole; Hemostatics; Pantoprazole

Criteria

Inclusion Criteria:

• Bleeding peptic ulcers with major stigmata of recent hemorrhage

• All of these major SRH are treated by local injection of diluted epinephrine 1:10000 with or without combined therapy with a heater probe, argon plasma coagulation, band ligation, or hemoclip therapy

Exclusion Criteria:

• Bleeding due to tumor or cancer

• Bleeding due to the presence of a Dieulafoy lesion

• Ulcer bleeding due to mechanical factors (i.e., gastrostomy tube induction)

• Proton pump inhibitors use within one week before enrollment

• Failure to establish hemostasis under gastroscopy

• Hypersensitivity to esomeprazole, pantoprazole, or any component of the formulation

• Previously participated in the study