The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial)
Status:
Recruiting
Trial end date:
2027-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether treatment of HPV-related oropharyngeal
squamous cell carcinoma in patients with undetectable postoperative HPV circulating tumor DNA
(cfHPVDNA), either with transoral robotic surgery (TORS) alone or combined with reduced doses
of radiation and chemotherapy can result in cancer control and survival comparable to those
previously reported with standard therapy.
The hope is that with this newer approach, the long-term complications from chemotherapy and
radiation can be reduced.