The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to

• Determine blood peptide levels and investigate any tissue gradients of apelin in patients with idiopathic pulmonary arterial hypertension and healthy volunteers.

• Evaluate the effect of exogenous apelin infusion on exercise performance in healthy volunteers and patients with idiopathic pulmonary arterial hypertension.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Imperial College London

Criteria

Inclusion Criteria for Control group:

• Structurally normal heart by 2D Echocardiography

• Pulmonary artery pressure < 25mmHg

• Tricuspid velocity < 2.5ms-1

Inclusion Criteria for Treatment group:

• Clinical diagnosis of Pulmonary arterial hypertension that is idiopathic, associated with anorexigens associated with connective tissue disease or familial

• Able to give informed consent

• Mean pulmonary artery pressure > 25mmHg, pulmonary capillary wedge pressure < 15mmHg, with normal or reduced cardiac output.

Exclusion Criteria for ALL group:

• Bleeding diathesis (PT > 14 sec to aPTT > 40 sec)

• Pregnancy, or women of child bearing potential not on adequate contraception

• Renal or hepatic failure

• Severe valvular heart disease

• Left ventricular dysfunction (LVEF < 40)

• Chronic lung disease

• Malignant arrhythmias

• Chronic thromboembolic disease