The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether minocycline are effective in the treatment of negative and cognitive symptoms in schizophrenia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Central South University
• Treatments: Minocycline

Criteria

Inclusion Criteria:

• male and female,were aged 18-40 years

• were currently diagnosed with DSM-IV schizophrenia

• were able to comprehend the cognition test

• patients or guardian signed informed consent,were able to comprehend the procedure and aims of the study,agreed to join the study

• patient's current antipsychotic medication regimen must be stable

• must be in a stable living arrangement

Exclusion Criteria:

• had ever been hypersensitivity to minocycline or tetracycline;

• had acute,unstable,significant,or untreated medical illness besides schizophrenia

• were pregnant or breast-feeding;

• had a DSM-IV diagnosis of substance abuse or dependency;

• had a tendency to suicide or Violence,self-harm;

• had taken immunosuppressive agents in the preceding 3 months before study entry;

• had influenza or fever in the preceding 2 weeks before study entry;

• had a DSM-IV diagnosis of emotional psychosis,Mental retardation,etc.

• has suicidal attempts or ideation or violent behavior within the last 12 months

• patient has mental retardation or severe organic brain syndromes

• treatment with Electroconvulsive Therapy (ECT) within 6 months prior to screening