The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Phase 1 Sympathetic block leads to vasodilatation and increases in blood flow. However, regional hemodynamic changes of radial and ulnar artery after specific nerve block of brachial plexus remains unclear. The aim of the study is to assess the effect of specific nerve block of brachial plexus on hemodynamics of upper extremity, and provides evidence for further research in patient undergoing microvascular surgery.

Phase 2 There is no literature about dose-finding studies of sympathetic block after brachial plexus block. Little is known regarding the relationship between concentration of local anaesthetic and vasodilation of upper extremity. The aim of this randomized, double-blind, prospective dose-response study is to determine the ED50 and ED95 of ropivacaine in sympathetic block of upper extremity after supraclavicular block

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wenzhou Medical University
• Collaborator: Health and Family Planning Commission of Zhejiang Province, China
• Treatments: Ropivacaine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologist physical status I-III patients

• aged 18-70 yr

• weighing 40-80 kg

Exclusion Criteria:

• infection at the site of needle insertion

• coagulopathy

• international normalized ratio >1.4

• platelet count <80×109 litre-1

• allergy to local anaesthetics

• peripheral neurological disease

• peripheral vascular disease

• patients do not agree to sign the informed consent.