The Study of Warfarin Maintenance Dose in Chinese Patients

• Status: Unknown status
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

1. Title: Clinical study of the relationship between Pharmacogenomics and warfarin dose in Chinese patients

2. Drug: Warfarin

3. Design: To value the accuracy of warfarin Pharmacogenomics algorithm by the algorithm calculated dose and actual dose in the Chinese patients.

4. Hypothesis:Pharmacogenomic algorithm guided dose can help to predict warfarin dose in Chinese patients.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital
• Treatments: Warfarin

Criteria

Inclusion Criteria:

• Chinese patients

• Age >18y

• target INR 1.5~3.0

• Patients signed informed consent

Exclusion Criteria:

• Has hemorrhage disease, or tendency to significant bleeding

• Severe liver and kidney disfunction, serious infections, severe heart failure (NYHA heart function classification Ⅲ magnitude), severe pulmonary hypertension, abnormal thyroid function, respiratory failure, anemia, malignant tumor, blood disease

• patients with pregnancy or lactation;

• with cognitive impairment.