The Study of the Pathogenesis and Cognitive Behavioral Group Therapy in Obsessive-Compulsive Disorder
Status:
Completed
Trial end date:
2017-07-24
Target enrollment:
Participant gender:
Summary
This study intends to explore the pathogenesis of obsessive-compulsive disorder(OCD) by using
biological technologies such as genetics and imaging, and to evaluate the efficacy of group
cognitive behavioural therapy in OCD among the Chinese people. We also prepare to explore the
synergistic effect of the pharmacological treatment combined with group cognitive behavioural
therapy in OCD, and to find the biological and psychological index which can predict curative
effect.
This research includes case control study and randomized controlled single-blind study. At
baseline, we compare the dimensions of clinical symptoms, genetics and imaging between OCD
patients and healthy controls. The OCD patients are randomly assigned into pharmacological
treatment, psychological treatment or pharmacological combined with psychological treatment
for a 12-week treatment. After a 12-week treatment, the OCD patients will be divided into
valid and invalid groups according to the results of our randomized controlled study by
researchers: to our valid group, patients will continue the current treatment, and to the
invalid psychological or pharmacological treatment group, patients will have a 12-week
combined treatment. From the baseline, we will have a 9-month follow up for both OCD patients
and healthy controls.